A recent study carried out by Dr D Banerjee and Prof JC Kaski in the CVD and Renal Disease research group at CVSRC showed that patients with chronic kidney disease (CKD) have a higher inflammatory status compared to control patients, and that endothelial dysfunction and atherosclerotic changes correlate with inflammation.
Patients with CKD have higher incidences of cardiovascular morbidity and mortality than the general population. Prof Kaski and colleagues studied a cross-sectional population of 76 patients with CKD – 38 predialysis, 18 haemodialysis and 22 kidney transplant patients, and compared markers for endothelial dysfunction and early atherosclerosis with 65 control patients.
The results showed that CKD patients taken together have a higher inflammatory status than their non-CKD counterparts, suggesting that endothelial dysfunction and atherosclerotic changes correlate with inflammation.
Further reading
Recio-Mayoral A, Banerjee D, Streather C, Kaski JC. Endothelial dysfunction, inflammation and atherosclerosis in chronic kidney disease – a cross-sectional study of predialysis, dialysis and kidney-transplantation patients. Atherosclerosis 2011 Feb 18. [Epub ahead of print]